Effect of amine fluoride/stannous fluoride toothpaste and mouthrinse on dental plaque accumulation and gingival health.

OBJECTIVE: The aim was to investigate the influence of amine fluoride (AmF)/stannous fluoride (SnF2) containing toothpaste and mouthrinse on plaque accumulation and gingival health of young adults after 4 weeks use. SUBJECT AND METHODS: Forty-two young adults (mean age: 28.33 +/- 7.19 years) were examined for the Plaque Index (PI; Silness and Löe, 1964) and Gingival Index (GI; Löe and Silness, 1963) scores, and divided randomly into two groups. Both groups used AmF/SnF2 containing toothpaste twice a day for 3 min toothbrushing, and one group after toothbrushing rinsed with AmF/SnF2 containing mouthrinse for 30 s. After 4 weeks the probands were re-examined. RESULTS: Statistically significant decrease in dental plaque (PI) and gingival (GI) index values were found at the end of the study. The reduction of PI and GI values was significant in all groups but it was higher in the combined (toothpaste + mouthrinsing) group, than using toothpaste only. CONCLUSION: The regular combined use of AmF/SnF2 toothpaste and mouthrinse was more effective in the reduction of plaque accumulation and maintenance of gingival health than the toothpaste alone.

[Effect of smoking on the development of oral leukoplakia]. / A dohányzás hatása a szájüregi leukoplakia kialakulására.

The increase in cancer mortality throughout the world justifies the study of its causes and development. Oropharyngeal cancer is ranked on the sixth place, Hungary with the highest mortality among 46 countries. Tobacco use is implicated in the development of oral cancer, and oral leukoplakia as well. The aim of the study was to give an overview on the connection between tobacco use and oral leukoplakia. Summarizing the literary data strong evidence has been found on the role of smoking in the development both of oral cancer and oral leukoplakia. Epidemiologic patterns of cigarette-smoking show a steep increase in Central-European countries, especially in Hungary. Cross-sectional studies indicate higher prevalence rate of leukoplakia among smokers, with a dose-response relationship between tobacco use and oral leukoplakia, while intervention studies show a regression of the lesion after stopping the smoking habit.

Tobacco use and oral leukoplakia.

The increase in cancer mortality throughout the world justifies the study of its causes and development. Hungary has the highest mortality rate from oropharyngeal cancer out of forty-six countries. Tobacco use is implicated in the development of oral cancer, and oral leukoplakia as well. The aim of the study was to give an overview of the connection between tobacco use and oral leukoplakia, considering the epidemiologic patterns of tobacco habits, the prevalence of smoking in oral leukoplakia, and the effect of smoking on clinically healthy oral mucosa with special respect to central Europe and Hungary. In the data, strong evidence has been found for the role of smoking in the development of both oral cancer and oral leukoplakia. Epidemiologic patterns of cigarette smoking show a steep increase in central European countries. Cross-sectional studies show a higher prevalence rate of leukoplakia among smokers, with a dose-response relationship between tobacco use and oral leukoplakia, and intervention studies show a regression of the lesion after stopping the smoking habit.

Risk group assessment of oral precancer attached to X-ray lung-screening examinations.

The mortality rate of oral tumours in Hungary, as in some other countries, is increasing. In order to assess risk groups for oral cancer and precancer, oral examinations were carried out as part of the X-ray screenings for lung cancer in the 3rd district of Budapest, Hungary. There were 5,034 adults who participated voluntarily in these investigations. After completing a questionnaire with 23 questions, a short oral examination was performed. Males comprised 57.7% of the group, and the age-distribution among men and women was similar. Oral precancerous lesions were found in 3.7% of the whole group, in 3.3% of those with leukoplakia, and in 0.4% of those with oral lichen planus. The prevalence of leukoplakia in men was 5.8%, and in women 1.5%, with significantly higher prevalences in men and women over 40. Among the examined persons there were 31% who were smokers, and 6% reported that they were regular consumers of alcohol. Fifty-four percent of those examined reported that they did not visit the dentist regularly. Oral complaints came mostly from those with lichen planus. The described model, where the oral screening examinations are done in conjunction with other examinations, in a so-called multiphasic screening system, seems to be a worthwhile approach for early diagnosis of oral cancer and precancer.

[Study of the permeability of oral leukoplakia]. / A szájüregi leukoplakia permeabilitásának vizsgálata.

The significant increase in the mortality rates of oral carcinoma speeded up the research on the mechanisms of tumor promoting and inhibiting factors. Results of previous studies in the USA showed different permeability between keratinized (hard palate, gingive) and non-keratinized (floor of the mouth) regions of the oral mucosa, and a corresponding difference in lipid composition. Aim of this study was, to compare the permeability and lipid composition of leukoplakia of the oral mucosa with healthy specimens from the same region, in order to assess a possible enhancement or inhibition in the barrier-function, in cases of pathological keratinization. Results of the measurements showed, that hyperplastic leukoplakia areas were more permeable for the NNN carcinogens contained in tobacco, and even clinically healthy sites showed a higher permeability, that oral mucosa of non-smokers. These data together with the results of lipid analysis, point to the possible generalized changes--caused by smoking--in the oral cavity, even before the appearance of clinical signs.

[Epidemiologic survey of tongue lesions and analysis of the etiologic factors involved]. / A nyelvelváltozások epidemiológiai felmérése és aetiológiai tényezöinek vizsgálata.

The prevalence of tongue lesions, and relationships with different systemic diseases, according to the international literature of epidemiologic studies were reviewed. The data were compared with a Hungarian investigation of 5034 individuals, between 1992 and 1995 in Budapest. Tongue lesions were found in 22.76% of the examined individuals. The ratio was similar in women (51%) and men (49%). Fissured tongue was found in 21.49%, geographic tongue in 2.21%, atrophic tongue in 0.12% and central papillar atrophy in 0.70%. These data agree in general with the epidemiological data found in the international literature. Some rare tongue alterations were also investigated. Lingua indentata was found in 1.49% and hypertrophy of papillae foliatae was found in 0.20%. The relationship with different systemic diseases was the following: In diabetes mellitus tongue lesions were found in 29.03%, in hypertension in 28.63%, connected to heart- and vascular diseases in 25.15%, to haematologic diseases in 17.54%. Tongue lesions were found in 23.86% in the case of liver disease, in 22.38% in gastrointestinal diseases and in 20.69% associated to tumors. In the case of Candida's infection tongue alterations were found in 41.6%, in smokers in 23.72%. Tongue lesions caused complaints rarely, only in 2.27%. The recognition of tongue lesions may be helpful in the early diagnosis of systemic diseases.

The effect of bicarbonate/fluoride dentifrices on human plaque pH.

The acidogenic response in dental plaque after rinsing with sodium bicarbonate/fluoride dentifrice slurries was studied using three intra-oral models. In the first model, resting plaque pH was monitored in mesiobuccal plaque on upper molars and premolars in six healthy subjects after abstinence from normal oral hygiene for three days. These measurements were followed by a three-minute rinse with 10% sucrose and, following a two-minute interval, a three-minute rinse with a test dentifrice slurry. After the test dentifrice rinse, pH was monitored at regular intervals up to 60 minutes. Flow rate, pH and buffer capacity of stimulated saliva were also determined. Changes in resting pH, plaque pH minima, and maximum pH drop were calculated. A clear elevation in the resting pH was observed after bicarbonate/fluoride dentifrice rinses, and a significant increase was obtained in the pH minima. The smallest pH drop also was found after treatment with the bicarbonate/fluoride dentifrice rinse treatment (p < 0.02). A second model using telemetric partial dentures with interproximally placed micro-antimony pH electrodes was used to study the effects of rinsing with increasing concentrations of sodium bicarbonate and calcium carbonate solutions, and with a fluoride dentifrice containing sodium bicarbonate. The response to these treatments was found to be rapid, dose-dependent, and was the greatest from the sodium bicarbonate. A third model used 24 subjects to assess the effects of sodium bicarbonate/fluoride dentifrice on plaque pH before and after a glucose challenge. The use of the bicarbonate/fluoride dentifrice resulted in significantly less measurable plaque acid than the fluoride dentifrice treatment. Collectively, these results indicate bicarbonate in dentifrice to be an effective buffering agent for stabilizing the pH and neutralizing plaque acids in dental plaque.

[Treatment of xerostomia with lactoperoxidase-containing mouthwashes and toothpaste]. / A xerostomia kezelése laktoperoxidáz-tartalmú szájápoló szerekkel.

The aim of the study was to determine the effect of a lactoperoxidase--hypothiocyanate enzyme system on the subjective complaints and symptoms of patients suffering from "dry mouth syndrome" with diseases of the oral mucosa. The objective changes in the oral microbiological flora and cytological pattern were also assessed. The lactoperoxidase-enzyme system-containing products--like Oralbalance gel (in combination with Biotène toothpaste)--seems to be a useful tool of choice for symptomatic therapy in patients, complaining of "dry mouth syndrome".

[Stomatologic mass screening in the 3rd District of Budapest]. / Stomatoonkológiai szürövizsgálatok Budapest III. kerületében.

Stomatooncological examinations, related to the lung-screening process in the 3rd district of Budapest have been performed for one and a half year. Screening examinations of 2213 non-selected patients identified precancerous lesions in 127 cases: leukoplakia in 5.74%, oral lichen in 0.36%. Fifty-seven percent of the patients never or only in painful cases visited the dentist. Based on their findings, the authors claim to continue this screening program, and recommend the extension of this model to the whole population.

[Incidence of tongue diseases based on epidemiologic studies (review of the literature)]. / Nyelvbetegségek elöfordulásának gyakorisága epidemiológiai vizsgálatok alapján (irodalmi áttekintés).

According to the literary data the prevalence of fissured tongue varies between 0.8-60.0%, that of geographic tongue between 0.1-14.3%, that of atrophy tongue between 1.3-9.0% and that of the central papillary atrophy of the tongue between 0.0-3.35%. The wide-ranging diversity concerning the epidemiological data of tongue diseases can be explained by the multiple character of sampling, diagnosis and other methods used in different types of examinations. Disregarding the extremities and considering the average prevalence data, these agree in general with the epidemiological data found in Hungary in 1990: fissured tongue 8.8% geographic tongue 3.0%, atrophic tongue 6.37% and central atrophy of the tongue 0.35% prevalence.